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Immunology Medical Immunology Medicine

What is Inflammasome?

Definition – The inflammasomes are innate immune system receptors and

Image of CASP1

sensors that regulate the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules derived from host proteins¹.

These are an important component of Innate immunity because they can recognize the molecules released by the pathogen even without any previous exposure from such molecules. The recognition triggers the following chain of events –

Mechanism of Inflammasome action

The Ultimate result is cell death due to Pyroptosis.

Image Attribution

  • CASP-1: By Emw – Own work, CC BY-SA 3.0, Link
  • Mechanism of Inflammasome action: Dr. Arnab Mukherjee

Reference

Further Reading

Author

Dr. Arnab Mukherjee

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